Endocrine Abstracts

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

Background: Although primary hyperparathyroidism (PHPT) has been associated with diabetes mellitus (DM), the etiological link is not clear and the effect of parathyroidectomy is controversial.The aim of this observational study was to investigate the metabolic link between calciotropic hormones and glucose metabolism in PHPT patients before and after parathyroidectomy.Methods: Twenty-four consecutive patients with PHPT (Group-A) without DM were included ...

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

Background: Monogenic Diabetes is relatively rare, representing only 1–2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as Type 1 Diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members.Methods: Case report.Results: We describe a case of a young patient who presented with hyperglycemia in the absence of ketosis and following genetic testing, he proved to h...

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Background: Previous research suggests an association between specific genetic variations and interindividual variability in response to treatment with glucagon-like receptor agonists (GLP-1 RAs) in patients with type 2 diabetes mellitus (T2DM). We aimed to evaluate the role of CTRB1/2 rs7202877 (T>G) polymorphism in glycemic control and weight loss response to liraglutide among Greek patients with T2DM and to identify clinical factors related to prediction of res...

Background: Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium h...

Background: Primary hyperparathyroidism (PHPT) has been linked to glucose homeostasis disorders, leading to insulin resistance and type 2 diabetes mellitus. Previous small studies evaluating the effect of parathyroidectomy (PTX) on various parameters of glucose metabolism have produced conflicting results. The impact of PTX on incretin hormone levels has not been studied yet. The aim of this pilot study was to investigate the effect of PTX on markers of glucose metabolism and ...